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Multiple physiological and pathological states, including aging (11,12), obesity (13), and lipodystrophic conditions with excess visceral obesity, as in HIV-infected patients (14), are associated with reduced GH secretion

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167,169 Through functional insights and expression quantitative trait loci (eQTL) analyses, several loci have identified probable causal genes, such as SLC2A9, ABCG2, PDKZ1, SLC22A11 (OAT4), and INHBB