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scindens associated with secondary bile acid production was found to diminish the proportions of Th1 cells, Th17 cells, and DCs in the spleen of EAU mice, emphasizing the systemic immunomodulatory effects of specific gut microbes (73)

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Although less likely, such a scenario is not unusual, and has been visualized in the prototypical 2 adrenergic receptor: both ligand-free and antagonist-bound 2 adrenergic receptors can form a complex with nucleotide-free Gs 22,23