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Obesity pharmacotherapy: incretin action in the central nervous system

Statistical analysis Data were statistically analyzed using SPSS (version 19.0.1, Chicago, Illinois, USA) for Windows

It completed Phase 2 trials in obesity [3] and type 2 diabetes [4] and moved into a Phase 3 program (TRIUMPH)

The -aminoadipic-6-semialdehyde is catabolized to -aminoadipic acid via the action of the NAD + -dependent enzyme, aldehyde dehydrogenase 7 family member A1 (encoded by the ALDH7A1 gene), originally identified as -aminoadipic semialdehyde dehydrogenase (AASA dehydrogenase: AASADH)

Within the GLP-1 sequences, the alanine at position 2 is substituted with a glycine residue to confer protection against DPP-IV