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229 Mechanistically, PERK activation via ERAD deficiency promotes aberrant mammalian target of rapamycin (mTOR, alternatively termed the mechanistic target of rapamycin) signaling and HSC hyperproliferation

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By early 2026, FDA had publicly announced enforcement actions against multiple compounded GLP-1 telehealth platforms, and in April 2026 formally proposed removing semaglutide, tirzepatide, and liraglutide from the 503B outsourcing bulks list - with a public comment period running through June 2026