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The authors of one trial (95) included in the above-mentioned meta-analysis (89) noted that little cognitive decline was observed in the placebo group over their two-year trial, which may have limited their power to detect an effect of the B-vitamin intervention (95)

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Anderson ME, Nilsson M, Sims NR

Biopsy showed diffuse lymphocytic infiltration, lymphoid follicles and germinal centers, atrophy of thyroid follicles, oxyphilic cytoplasm, and dense fibrosis