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SLC19A1, a gene encoding a membrane folate carrier, was reduced in obese WAT and induced global DNA hypermethylation of chemokine C-C motif chemokine ligand 2 (CCL2) that is a key factor in WAT inflammation, 219 resulting in increased CCL2 protein secretion and the development of IR in obese

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Antioxidants, such as vitamin C (Vit-C), vitamin E (Vit-E), glutathione, and N-acetylcysteine, represent a potential therapeutic strategy