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As rates of obesity remain high in the hemophilia population, more individuals may be managing both diabetes and hemophilia

In March 2011, the FDA placed the trial on clinical hold due to GMP compliance issues at the contract manufacturer not safety concerns with RGN-352 itself

doi: 10.1016/j.molcel.2020.11.024 19 JiangXStockwellBRConradM

FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT-1/PGC- pathway

Ideally, our findings should be replicated using a validation cohort, however we are limited by the number of large contemporaneous cohorts available to study