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5.4 Acute Kidney Injury Due to Volume Depletion There have been postmarketing reports of acute kidney injury, in some cases requiring hemodialysis, in patients treated with GLP-1 receptor agonists, BYETTA [see Adverse Reactions (6.2)]

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Studies have found that astragaloside IV can also induce the expression of GPX, SOD, as well as catalase, and ameliorate mitochondrial oxidative stress via Keap1-Nrf2-ARE signaling pathway in AKI and CKD models (Yan et al., 2017