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Notably, interferons, as well as IL-2, IL-1, and IL-6, may induce indoleamine-2,3-dioxygenase (IDO), the enzyme responsible for the catabolism of tryptophan into tryptophan catabolites (TRYCATs) [18]
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W badaniu fazy II efpeglenatyd podawany raz na miesic (po fazie wstpnej titracji tygodniowej) znaczco obniy HbA1c vs placebo (rnica ~0,7% po 4 miesicach) i redukowa mas ciaa o ~2 kg (Efficacy and safety of once-monthly efpeglenatide in patients with type 2 diabetes: Results of a phase 2 placebo-controlled, 16-week randomized dose-finding study PubMed)
The commenter cited the technical expertise required by the technologist and the additional hardware and software costs as justification for the higher-level APC assignment