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In vivo, however, GLP-1GIPLani outperforms GLP-1RGIPR co-agonism and semaglutide to further decrease body weight, food intake and hyperglycaemia in mice with diet, or genetically-induced obesity

While its exact GLP-1 modulating effects are still under investigation, it has long been recognized for its blood sugar-lowering properties, believed to involve enhanced glucose uptake, improved insulin signaling, and possibly indirect effects on incretin hormones