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Naive male mice subjected to intraperitoneal KYN treatment, the product of IDO, also produces depressive-like behavior in a dose-dependent manner [114], potentially because high levels of KYN would lead to a build-up of downstream metabolites like 3-HK

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They found that repeated AMPH administration increased the HDAC function in the prefrontal cortex (PFC) without changing BDNF protein or mRNA levels, while the administration of sodium butyrate partially reversed the HDAC activity