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In a therapy known as autologous chondrocyte implantation (ACI), doctors harvest a patient's chondrocytes (cartilage cells), which are then multiplied outside the body and returned to the damaged joint
When postprandial glucose and/or fasting blood glucose are sufficiently high, the polyol pathway (and OxS) will be activated in cells relying on GLUT1, e.g., endothelial cells [109,110]
446 However, pathological effects emerge when immune clearance fails, leading to senescent cell accumulation and SASP-driven fibrosis in the tissue microenvironment
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Conings S, Tseke F, Van den Broeck A, et al
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