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Conventional surgical methods, including the use of scalpels, bur abrasion, cryosurgery, radiosurgery, gingival grafting, electrocautery, and lasers, have been found to be effective in treating hyperpigmentation in a single session.[4] Gul et al ., in a systematic review and meta-analysis, compared conventional and advanced gingival depigmentation techniques

However, the initial adjustment period may cause temporary symptoms that seem contradictory to these benefits

Casimersen: first approval

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