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Another small trial, the Effect of Semaglutide 2.4 mg Once Weekly on Function and Symptoms in Subjects with Obesity-related Heart Failure with Preserved Ejection Fraction (STEP-HFpEF) trial assesed semaglutide efficay in patients with preserved LVEF (LVEF 45%) and obesity (BMI 30 kg/m 2 )

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GLP-1R contributes to microglial activation in the TNC in NTG-induced CM mice We have indicated that chronic NTG stimulation induces an increase in the number and activity of microglia in the TNC

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