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Others may cause developmental delays, seizures, or mental health symptoms

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Melanotan-1 (afamelanotide, marketed as Scenesse for erythropoietic protoporphyria) binds selectively to MC1R with minimal MC4R affinity, producing melanogenesis without appetite suppression, nausea, or erectile effects

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Circulating tumor DNA as a predictive biomarker for pathologic response after treatment with neoadjuvant immunotherapy for localized dMMR/MSI-H colorectal cancer