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GSH depletion causes oxidative stress and lipid peroxidation To evaluate the downstream effects of GSH depletion, we measured soluble ROS in RPE cells treated with Cys 2 starvation, BSO, or erastin by flow cytometry using the fluorescent probe H 2 DCFDA

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When blood pressure drops, baroreceptors in the carotid arteries and aortic arch detect the change and trigger compensatory responses

However, when the oxidant level exceeds the reducing abilities of cells, ROS can lead to cellular damage through the oxidation of biomolecules, such as proteins, lipids, and DNA [8]

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