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[PubMed: 19836369] 35

Yes, though most are mild and temporary

Rats receiving the large capsule showed increased glial proliferation, brain swelling, and angiogenesis, while those receiving small doses showed preservation of a large number of tyrosine hydroxylase-positive fibers and a neuroprotective effect on dopamine neurons, indicating that VEGF at low doses can potentially support PD treatment (Yasuhara and Shingo 2005)

Completing full protocol durations rather than stopping when symptoms resolve helps optimize long-term tissue quality and reduces re-injury risk

Both intermittent dosing schedules (injections on specific days) and continuous daily administration showed benefits, suggesting some flexibility in protocol design