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That bioavailability hurdle is why different delivery systems (liposomal, sustained-release, S-acetyl, sublingual) exist, and why choosing the right form matters as much as choosing the right brand

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A GST mutant in which four glutamine residues were replaced with asparagine (GST 4QN ) exhibited a glutathione binding affinity similar to that of wild-type GST and could be purified by glutathione affinity chromatography