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The fact that a solvent-exposed hydrocarbon stapling motif (1907) provided the greatest increase in FAK FAT binding was unexpected, as another stapled peptide drug candidate ATSP-7041, which targets the p53-MDM2/MDMX interaction 34 , demonstrates high-affinity binding through a staple on the lateral side of the alpha-helix
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Your body produces glutathione using amino acids like cysteine, glycine, and glutamine