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Prior authorization : Before starting coverage, Aetna typically requires documentation of a type 2 diabetes diagnosis or evidence of established heart disease or kidney disease in addition to type 2 diabetes

Avoid: Repeated freeze-thaw cycles, excessive heat exposure, prolonged exposure to air, direct light exposure, contamination of the vial stopper

Based on preclinical data on -ketoglutarate, Bryan takes 1 gram of it twice daily

doi: 10.1038/s41585-018-0003-3 3 ChoyJTEisenbergML

COMT, a blood-borne enzyme, mediates the most common form of 2- or 4-hydroxyestradiol inactivation, in addition to glucuronidation and sulfation