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Moreover, phospho-BCL-XL (Ser62) stabilizes G2 arrest by binding to and co-localizing with Cdk1 (cdc2) in nucleolar structures to avoid rapid nucleolar disassembly associated with mitosis onset, playing an unexpected role in the G2 phase checkpoint downstream of DNA damage distinct from its anti-apoptotic function 22

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The oral health of South Asian five-year-old children in deprived areas of Dudley compared with white children of equal deprivation and fluoridation status

Acute liver toxicity may exhibit clinical symptoms of severe stomach pains, nausea, vomiting, and upper-right-quadrant abdominal sensitivity, leading some to naively take more acetaminophen for pain relief

Specifically, chronic inflammation in RA can lead to long-term changes in the central nervous system (CNS), resulting in heightened pain sensitivity (hyperalgesia) and pain from non-painful stimuli (allodynia) (Sa et al., 2020