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We start every patient on the lowest dose for safety precautions and to give the body time to adjust to the medication

The standard protocol allows for increases every four weeks, and many patients need to progress through multiple dose levels before finding their optimal therapeutic dose

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doi:10.1146/annurev-pharmtox-010611-134540, PMID: 23020296 Menzies V, Lyon DE, Archer KJ, Zhou Q, Brumelle J, Jones KH, Gao G, York TP, Jackson-Cook C (2013) Epigenetic alterations and an increased frequency of micronuclei in women with fibromyalgia