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According to Ramos Jr., there are a few key ingredients many pre-workouts have in common for optimal efficacy: A solid pre-workout includes caffeine (for energy), creatine (for power) and citrulline malate (for blood flow). Of course, the ratio of these ingredients matters, too, to ensure these formulas are safe and can help you reach your specific fitness goals

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SURMOUNT-OSA studied tirzepatide in obstructive sleep apnea (NEJM 2024)

In the trial, three individuals were instructed to follow a reduced-calorie diet for eight weeks that includes a daily calorie intake of 1000 kcal per day

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