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Research carried out during the last two decades has made clear that inhibitory synapses undergo short- and long-term forms of plasticity and numerous examples of activity dependent changes in synaptic strength of GABAergic synapses have been described in different brain areas, including hippocampus and cortex (Gaiarsa et al., 2002

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50% for vitamin C and 40% for tretinoin), without the irritation or photosensitivity that retinoids commonly cause

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