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The degree to which leptin and insulin stimulate overall GLP-1 secretion is still unclear, but GIP-mediated GLP-1 release has been shown to occur in rodents via acetylcholine release by the enteric nervous system

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Ozempic is administered once weekly via injection and is also used to reduce the risk of major cardiovascular events, such as heart attack or stroke, in adults with type 2 diabetes and known heart disease

Caloric restriction can trigger adaptive responses that may affect muscle metabolism, though these effects vary considerably between individuals

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