Following centrifugation at 300 g for 5 min, the cell pellets were resuspended in phosphate buffered saline (PBS) and then analyzed with a NovoCyte flow cytometer (Agilent, CA, USA)
As well, activated microglia expressing a higher concentration of NADPH oxidase enzyme promotes inflammatory reactions and the release of ROS (Hirsch and Standaert 2021)
7.3 Targeting FSP1/CoQ 10 pathway Intrastriatal administration of CoQ 10 showed higher efficacy in exerting neuroprotective effects than oral CoQ 10 delivery in a rat PD model, requiring 17,000 times lower dose (241)
Microscopic examination reveals lentiginous melanocytic hyperplasia that is usually distributed along the tips of rete ridges (Fig
b , FSC curves of the final refined model versus the final cryo-EM map (full dataset, black), of the outcome of model refinement with a half map versus the same map (red), and of the outcome of model refinement with a half map versus the other half map (green)