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30 Additionally, a phase 2 trial demonstrated that once-weekly retatrutide in patients with obesity and metabolic dysfunctionassociated steatotic liver disease resulted in a significant reduction in liver fat and an improvement in insulin sensitivity

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Two of the few recently recognized small molecules that succeeded in entering clinical development, namely LY3502790 and PF-06882961, activate the canonical G protein signaling activity only in the GLP-1 receptor with Trp33 ECD [38,42]