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In 1985, Takei introduced the papilla preservation technique that allow to access the defect and seal the interdental soft tissues after cleaning and grafting [56]

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Phase 2 Body Composition Findings Average total weight loss at 12 mg: 24.2% Fat mass reduction: Significantly greater than placebo and comparator drugs Lean mass preservation: Comparable or superior to existing treatments Visceral fat reduction: Particularly pronounced (correlating with metabolic improvements) What makes these findings particularly relevant for bulking applications is the context of how participants were eating