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Nature 566 , 538542 (2019)

The SELECT cardiovascular outcomes trial (Lincoff et al., 2023, New England Journal of Medicine) enrolled 17,604 adults with obesity and established cardiovascular disease no diabetes, and demonstrated a 20% reduction in major adverse cardiovascular events (MACE) with 2.4mg semaglutide versus placebo

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doi:10.1021/ja01853a512