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however, low intake and marginal deficiency have been shown to be relatively common around the world, and may be a contributing factor in cardiovascular disease, sarcopenia, frailty, and increased mortality in the elderly

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From April 1, 2026, the EDQM will reject non-compliant CEP applications at the point of submission

The more cautious interpretation is that patients who receive GLP-1 receptor agonists may differ in important but incompletely measured ways from those treated with insulin or metformin, including overall health, treatment access, healthcare follow-up, or cardiometabolic care intensity