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The dismutation of O 2 . results in the formation of hydrogen peroxide (H 2 O 2 ), which can lead to elevated levels of other potentially harmful reactive oxygen and nitrogen species (ROS, RNS) 2

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The activated Pers and Crys stimulate the activities of casein kinases 1/ and inhibit the transcriptional activity of the CLOCK/BMAL1 by inhibiting the binding to the E-box response element

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