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For the same reason above, it is possible that dehydro-alanine (acrylate) glutathione can inactivate the binding capacity of GCLC to form the holo-enzyme

Francesca Rizzollo Patrizia Agostinis Ferroptosis and Oxidative Stress Iron is indispensable for cellular metabolism yet potentially cytotoxic, making its intracellular handling a fundamental determinant of cell fate decisions

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10.2174/1389201025666230830125147 86 GutzietO.IluzR.Ben AsherH.SegalL.Ben ZviD.GinsbergY.et al (2021)

Intrinsic toxicity of the cellular prion protein is regulated by its conserved central region