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Oxyntomodulin, a gut-derived peptide hormone, activates both the GLP-1R and the GCGR, although, with reduced affinity compared to GLP-1 and glucagon, respectively

--- ## Storage Rules After Reconstitution | Condition | Temperature | Maximum Duration | |-----------|-------------|-----------------| | Refrigerator (ideal) | 3646F (28C) | 28 days from reconstitution | | Room temperature (brief excursion) | Under 77F (25C) | 2 hours maximum | | Frozen | Below 32F | Never discard immediately | **Storage do's:** - Store in the original vial, upright - Keep in the refrigerator door shelf or middle shelf avoid the back where freezing can occur - Protect from light (store in original box or wrap in foil) - Remove from fridge just before drawing your dose

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The co-administration of AST with FPN substantially decreased the astrocytic reaction, evident in the significant decreases in the mean area percentages of GFAP in cerebral and cerebellar tissues relative to FPN-administered rats mean values

[10] [11] Eligibility is assessed on an individual basis by a clinician in line with NICE guidance