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On multivariable logistic regression analysis, higher serum CysC (OR 2.58, 1.2-5.6), lower baseline eGFR (OR 0.10, 0.04-0.27), lower mean arterial pressure (OR 0.95, 0.91-0.99), presence of fraility (OR 4.78, 1.99-11.44) and the use of beta-blockers (OR 2.63, 1.23-5.65) significantly predicted the development of AKD at 3-months

Glutaredoxin is homologous to the disulfide-reducing thioredoxin and shares similar binding modes of the protein substrate

Thus, sideromycins may be vulnerable to the same antibiotic resistance mechanisms faced by traditional antibiotic therapies

Results: In the DIO mouse model, where ALG-055009 was administered QD or BID for 28 days, dose-dependent increases in selective THR-induced liver gene expression were observed and were associated with reductions in serum total and LDL-C

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