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Research has shown that macrophage activation is accompanied by rapid NAD+ depletion driven by CD38 upregulation and PARP activation, and that NAD+ repletion can modulate the inflammatory response of activated immune cells

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[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Gastaldelli A, Cusi K, Fernndez Land L, Bray R, Brouwers B, Rodrguez