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Cheng F, Jen J, Tsai T
Koppula P, Zhuang L, Gan B
Multi-omics analyses were employed to decipher the underlying molecular and metabolic mechanisms
For example, IB kinase (IKK) promotes the ubiquitination of NRF2 by activating the phosphorylation of CYLD, which in turn inhibits CYLDs deubiquitination activity, further exacerbating oxidative stress damage in the kidneys of obesity-related nephropathy (ORN) [19]
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