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Sotagliflozin and kidney outcomes, kidney function, and albuminuria in type 2 diabetes and CKD: A secondary analysis of the SCORED trial

In our study, we used this drug as a prototypic Nrf2 activator molecule to provide a proof of concept that the Nrf2 signaling pathway can be pharmacologically activated to increase the detoxifying capacity of the choroid plexus during the postnatal period

Kidney-targeted delivery systemssuch as PEGylated lipid nanoparticles (LNPs) modified with renal tubular cell-targeting ligands (e.g., vitamin B12, which binds to cubilin on PT cells)have shown promise in preclinical studies, increasing renal Fer-1 accumulation by 510-fold and reducing systemic toxicity

Newer research shows that insulin levels must be quite high for adequate amounts of L-carnitine to enter muscle cells, where it performs the majority of its work.[8] On the flipside, taking L-carnitine enhances insulin's actions at the muscle cells, helping to deliver more glucose into the muscle cells as well as more L-carnitine

Studies indicate that the BPC-157 + TB-500 combo enhances collagen production and ECM deposition, leading to more durable tissue scaffolds