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Data were evaluated for distribution patterns using tests including Shapiro-Wilk and KolmogorovSmirnov tests and by visual inspection of the distribution residuals

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Consistently, the mRNA and protein levels of hepatic CYP8B1 were elevated, while the percentage of 12-OH BAs was increased and the proportion of non-12-OH BAs was reduced in the gallbladder bile, ileum, liver, serum, and urine in MMI mice compared to untreated control mice (CT mice) (Supplementary Fig