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10.1111/jpi.12326 19 ChenS.DaiM
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Year 2014 Mechanisms underlying the antihypertensive effects of garlic bioactives Year 2014 Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance Garlic and RAAS One other mechanism by which garlic may elicit its antihypertensive effects is inhibition of ACE, which is a major component of the renin-angiotensin-aldosterone (RAA) system
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The McCoy 2013 paper extended this work by introducing N- and C-terminal modifications designed to enhance metabolic stability and hydrophobicity, ultimately producing Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) as an orally active, BBB-permeable analog [2]
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