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Remarkably, TNFR1 flops to protect the oligodendrocytes from immune-mediated damage in multiple sclerosis and experimental autoimmune encephalomyelitis, and neurons from retinal ischemiareperfusion injury [46]

Mojarad-Jabali S, Roh KH (2025) Peptide-based inhibitors and nanoparticles: emerging therapeutics for Alzheimers disease

Sci Rep 6(1):29359

And viewed through this lens, its not totally far-fetched to imagine how 5-Amino-1MQ could improve energy metabolism in muscles, the heart, and the brain, potentially impacting obesity, insulin sensitivity, cardiovascular disease, and cognitive function