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GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity

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For glutathione IV therapy, a weekly or bi-monthly treatment schedule is preferred, depending on the bodys needs and the doctors recommendation

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A dynamic AspArg interaction is essential for catalysis in MPGES1 where mutation of R126 results in loss of PGE synthase activity 40, 41