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Statistical analysis of RNA-seq data is described in the Methods section

Biomarkers of Nutrition for Development (BOND): vitamin B-12 review

Protein Binding Capacity The protein binding capacity is up to 10mg/mL settled beads, as determined by purification of glutathione-S-transferase (GST) from E.coli cleared lysates, and quantified via spectrophotometry

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Ethics declarations Ethics approval and consent to participate All experiments with brain organoids were performed in accordance with the national and international ethics guidelines, and were approved by the ethics committee at the University of Luxembourg, Comit National dEthique de Recherche (CNER