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To further elucidate the molecular mechanism of RRM2 regulation of cell cycle, we examined the expression levels of cell cycle-related proteins (Cyclin A2, Cyclin E2, c-MYC, Cyclin D1, CDK2) in TPC-1 cells by Western blot

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This marked elevation in LVEDP suggests central congestion, irrespective of no change in afterload (systemic pressure), and is a hallmark of heart failure 20