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Aging and cataractous human lens display impaired redox homeostasis, decreased GSH deposition, disrupted GPX activity, increased content on iron redox, and promoted lipid oxidation

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Physical activity, sleep quality and stress all play a role too

By contrast, other phenolic compounds (52-55) exert anti-melanogenic properties by downregulating the cAMP/CREB signaling pathway and/or activating related caspases to trigger apoptosis of melanocyte cells (Table I)

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