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The risk is that small-molecule agonism of Class B GPCRs (the incretin receptor family) is historically difficult - the natural ligands are peptides, and achieving both potency and selectivity in a small-molecule scaffold against three Class B GPCRs simultaneously is a significant medicinal-chemistry achievement in its own right

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Tucker Davis Technologies (TDT) System III hardware and SigGen/BioSig software (TDT) were used to present the stimulus and record the ABR responses