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The EVOLVE study evaluated AXS-05 twice daily in 186 people with MDD who had at least one prior treatment for the current major depressive episode [144]

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Further supporting the role of LA as a zonulin inhibitor, one study found that LA treatment reduced both rearrangement and redistribution of actin and the tight junction-associated protein zonula occludens-1 (ZO-1) in Caco-2 brush-border-expressing cells that were exposed to AT-1002, a synthetic hexamer peptide derived from the active Zot fragment that has been shown to increase tight junction permeability (24)

Caspase activation in hair cells of the mouse utricle exposed to neomycin

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