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If slow titration does not work to minimize side effects, suggest small food portions and make sure any reflux symptoms are appropriately treated (a short course of a proton pump inhibitor is most commonly recommended) (Gorgojo-Martnez JJ et al, J Clin Med 2022;12(1):145)

We emphasize the need for a balanced diet, regular physical activity, and ongoing behavioral support to maximize the benefits of these medications and minimize the risk of weight regain

The effect on certain inflammatory biomarkers (TNF- and IL-17) was evident only in subjects with IBS-D, but changes in other inflammatory markers and in those related to oxidative stress were apparent regardless of IBS subtype

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By week six to eight, many people report that headaches have resolved or diminished substantially as their body reaches homeostasis with the new medication