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Structural biology-inspired discovery of novel KRASPDE inhibitors
Moreover, given that dopamine agonist treatment in PD is limited by their intolerable side effects and diminished effectiveness over time, we selected astrocyte-specific PKM2 as a target to break this vicious cycle and found that pyridoxine can dimerize PKM2 to restore GSH levels, providing neuroprotection in the MPTP mouse model beyond targeting dopamine receptors
Dual MAPK Pathway Modulation MAPK pathways receive dual modulation
Some argue that allowing peptides to be compounded will ensure a safer peptide supply
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