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2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes: developed by the task force on the management of cardiovascular disease in patients with diabetes of the European Society of Cardiology (ESC)

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Phase I data presented at the American Heart Association (AHA) 2025 meeting and published in The New England Journal of Medicine ( NEJM ) showed deep, dose-dependent reductions in ANGPTL3 (up to 89%) with corresponding decreases in triglycerides and LDL cholesterol, including in patients already on standard lipid-lowering therapy

Phase 3: Optimize both (weeks 9-16) Increase AOD 9604 to 300-500mcg daily based on tolerance