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Decreased CBF precedes the detectable changes of classical A and tau biomarkers, as well as brain atrophy, suggesting that reduced CBF could be a valuable biomarker in preclinical AD [138, 179]

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Some people naturally have stronger appetite suppression and metabolic flexibility, making 18+ hour fasts sustainable

Clinical data shows an average pace of 1 to 2 pounds weekly in early months, but individual weeks fluctuate based on hydration, sodium intake, hormonal cycles, and medication tolerance